Deantre Prince attended Charleston High School in Mississippi. He tallied 41 tackles and one interception as a senior. He earned a 4-star rating from ESPN, and 3-star ratings from rivals.com and 247 Sports. He chose to join Ole Miss over Michigan, Illinois, and Auburn.
As a true freshman in 2019, Prince tallied 25 tackles and 2 interceptions in 12 games. As a sophomore in 2021 he played in 13 games for the Rebels. He made 37 tackles and 2 interceptions.
His first full season as a starter cams in 2022 when he started all 13 games and logged 39 tackles, 1 TFL, 1 interception, and 11 pass breakups.
Prince returned for this season with the Rebels and once again started all 13 games. He registered 36 tackles, 5 TFL, 1 interception, and 5 pass breakups.